REACT-2.2: Feasibility of COVID-19 Self-testing

Which are the issues of self-testing? This study aims to assess the feasibility of finger-prick antibody testing at home to prove the design of the larger-scale COVID-19 studies


Keywords: SARS-CoV-2; COVID-19; virus; point-of-care diagnostics

Q&A with the REACT team: REACT researchers Dr Atchison and Prof Barclay host a public Q&A session on antibody testing.

Short of a vaccine, testing is the only way out of lockdown.

Prof ara darzi

Description of the Study:

  • Title: REACT-2: a study of SARS-CoV-2 antibody seroprevalence in the community in England.
    – Study 2: Public involvement and pilot testing to assess the feasibility of in-home self-testing for SARS-CoV-2 antibodies.
  • Principal Investigators: Steven Riley, Christina Atchison, Deborah Ashby, Christl A. Donnelly, Wendy Barclay, Graham Cooke, Helen Ward, Ara Darzi and Paul Elliott.
  • Centers of Implementation: Imperial College London, Imperial College Healthcare NHS Trust and Ipsos MORI.
  • Study Population: A small (n=20-30) but varied group of adults who do not have any medical conditions (or are taking medication) that might increase bleeding risk from self-delivered finger prick with a lancet.
  • Study Type: Cross-sectional study.
  • Design: Rapid iterative participatory approach involving members of the public at all stages of the REACT programme research process.
  • Methods: Volunteers are asked to do the antibody test and then complete an online questionnaire about their experience. A subsample (n=20) are asked to perform the test while being observed via videoconferencing and take part in a short interview after completing the test.

Objectives of the Study:

Principal Objective: To identify issues and concerns with carrying out finger-prick antibody tests at home in order to prove the design and experience of the larger-scale studies.

More about this Study:

Conclusions: The REACT-2 results and statistics can be found on this page.

REACT: The REal-time Assessment of Community Transmission (REACT) programme is a series of epidemiological studies that are seeking to improve understanding of how the COVID-19 pandemic is progressing across England. To do this, the programme is carrying out two major pieces of work that are looking at the possibility of using home sampling and testing to track the infection. REACT-1 programme is monitoring coronavirus infection levels over time, while REACT-2 programme is assessing antibody finger-prick tests and using these to estimate how far the virus has spread.

Together REACT-1 and REACT-2 will improve our understanding of the transmission of the virus in the community to help guide policies on continued social distancing and other control measures.

Other studies of REACT: « A study of SARS-CoV-2 virus prevalence in the community in England« , « Clinical and laboratory evaluation of SARS-CoV-2 lateral flow immunoassays« , « Acceptability and usability study of in-home self-testing for SARS-CoV-2 antibodies in a population-based sample » and « Usability and validity of LFIA self-testing in key workers, including the assessment of dry blood spots for SARS-CoV-2 antibody detection and saliva for SARS-CoV-2 viral detection ».

Added value: Study 2: Public involvement and pilot testing to assess the feasibility of in-home self-testing for SARS-CoV-2 antibodies, and the other COVID-19 studies within the REACT program have been commissioned by the Department of Health and Social Care.

Imperial College London



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