Raloxifene to treat inflammatory processes by COVID-19

This study aims to characterise the pharmacological profile of raloxifene against bradykinin receptors to treat inflammatory processes due to COVID-19


Keywords: nonpeptide bradykinin partial agonist; drug repurposing; Covid-19 therapies; raloxifene

Results:

Results
Functional efficacy study of raloxifene on CHO cells stably transfected with the B2 receptor (N=2). (a) Study of the agonistic effect of the compound compared to bradykinin; (b) study of the efficacy of the compound antagonizing bradykinin.

The good results of the different lines of research on raloxifene make it very likely that the compound is a good candidate as a drug against COVID-19.

Juan Jesús Pérez

Description of the Study:

  • Title: Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign.
  • Principal Investigators: Patricia Gomez-Gutierrez and Juan J. Perez.
  • Design: Through virtual drug screening they have searched for drugs capable of downregulating bradykinin signalling and have found raloxifene. Once the compound was identified in silico, a sample was sent to an external laboratory for in vitro characterisation to corroborate its new pharmacological profile.
  • Methods: Drug screening has been carried out using computer-aided drug design methodologies.

Objectives of the Study:

Principal Objective: To characterize the pharmacological profile of raloxifene towards the bradykinin receptors.

More about this Study:

Scientific Context: Approximately 20% of COVID-19 patients present a severe clinical picture and require intensive care. These individuals develop pneumonia of varying degrees that can progress to more severe stages and lead to organ dysfunction. In these severe cases of the disease, elevated levels of various pro-inflammatory molecules, a phenomenon known as cytokine storm, are observed. Recently, it has been found that an inflammatory mediator called bradykinin may be the precursor of this inflammatory process that affects the most severe patients and can be life-threatening.

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