MMR Vaccine and the Immune Response to SARS-CoV-2

Is the MMR vaccine involved in the immune response to SARS-CoV-2? This study aims to answer that question by investigating the effect of the MMR vaccine on COVID-19

What do you know about the MMR vaccine?

The MMR vaccine is a mixture of three attenuated viral components, administered by injection for immunisation against measles, mumps and rubella.

The first dose is generally given to children around 9 to 15 months of age, with a second dose at 15 months to 6 years of age and with at least 4 weeks between the doses.

This vaccine is routinely used around the world. Since it was introduced in its initial versions in the 1970s, more than 500 million doses have been administered in more than 60 countries.

Description of the Study:

  • Title: Involvement of the MMR Vaccine in the Immune Response to SARS-CoV-2 Infection.
  • Principal Investigator: Antoni Noguera-Julian.
  • Co-Investigators: Clàudia Fortuny, Victoria Fumadó, María Ríos, Anna Gamell, Sílvia Simó, Eneritz Velasco-Arnaiz, Miguel Lanaspa, Manuel Monsonís and Pilar Subirats.
  • Center of Implementation: Hospital Sant Joan de Déu Barcelona.

Objectives of the Study:

Principal Objectives: This study has four specific objectives:
(1) To determine the levels of rubella virus IgG antibodies in patients infected with SARS-CoV-2, with mild or severe disease, and in patients not infected with SARS-CoV-2.
(2) To correlate the levels of rubella virus IgG antibodies with various clinical and biochemical severity markers of COVID-19.
(3) To compare the current levels of rubella virus IgG antibodies with previous levels in those patients with available information.
(4) To compare the levels of rubella virus IgG antibodies and their evolution with the levels and evolution of the serological response to other infections with available vaccines.

More about this Study:

Sant Joan de Déu: The Hospital Sant Joan de Déu Barcelona is a university hospital specializing in the fields of pediatrics, gynecology, and obstetrics, which has a long history of more than 150 years, during which it has undergone many transformations and changes due to the need to adapt both to the social and health conditions of the time and to technological advances and the evolution of health care.

Other Kids Corona Projects:Susceptibility to COVID-19 in pediatric age: Study of cases and household contacts“, “SARS-CoV-2 seroconversion during the postoperative period in pediatric patients”, “Identifying SARS-CoV-2 in breast milk as a potential means of vertical transmission”, “Susceptibility to COVID-19 in pediatric age: Study of cases in school-like environments” and “Characterization of COVID-19 in the Pediatric Population: Study of Sero-surveillance and of Immunological and Biochemical Biomarkers of Disease Severity”.

Hospital San Joan de Déu leads this study about the effect of the MMR vaccine on COVID-19+ patients.

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