Autoantibodies As An Indicator Of Poor Prognosis In COVID-19

This study shows that 10% of patients with severe COVID-19 have neutralising antibodies against the cytokine interferon type 1


Keywords: COVID-19; subcutaneous interferon-beta 1b; type I IFN neutralizing autoantibodies; severity biomarkers

Not only confirms the prevalence of autoantibodies in a significant number of patients with a worse prognosis, but also correlates them with biochemical biomarkers already in clinical use, such as a decrease in lymphocytes number or increase in C-reactive protein, also, underline the predictive value of these antibodies against interferon.

Dra. AURORA Pujol

Description of the Study:

  • Title: Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain.
  • Principal Investigator: Aurora Pujol and Jesús Troya.
  • Co-Investigators: Paul Bastard, Laura Planas-Serra, Pablo Ryan, Montse Ruiz, María de Carranza, Juan Torres, Amalia Martínez, Laurent Abel y Jean-Laurent Casanova.
  • Centres of Implementation: Infanta Leonor University Hospital in Madrid.
  • Study Population: 47 COVID-19 patients with severe pneumonia.
  • Study Type: Cohort study.
  • Methods: They analysed stored serum/plasma samples and clinical data of COVID-19 patients treated subcutaneously with IFN-beta-1b from March to May 2020.

Objectives of the Study:

Principal Objective: To define the prevalence of IFN type I neutralising autoantibodies in a cohort of patients with severe COVID-19 pneumonia treated with IFN-beta-1b during hospitalisation and to analyse their impact on several clinical variables and outcomes.

More about this Study:

Scientific Context: Since the first case of pneumonia caused by SARS-CoV-2 was reported in Wuhan in December 2019, this virus has infected more than 79 million people and has been responsible for at least 1.7 million deaths over the world. Most of the patients infected by the new coronavirus do not present symptoms or these are mild, 3% develop pneumonia, and 0.3% progress to more severe conditions such as acute respiratory distress syndrome. However, the factors that determine the severity of the disease remain unknown, unraveling them could be determinant to improve treatment and prognosis of the disease.

Previous studies, with the participation of Dr. Aurora Pujol, geneticist and ICREA professor at the Bellvitge Biomedical Research Institute (IDIBELL), pointed out that the cytokine interferon type 1 could be playing a key role in the development of the most severe forms of COVID- 19. These studies showed that 10% of patients with severe forms of COVID-19 had developed their own antibodies against interferon. Furthermore, parallel studies demonstrated that mutations in the signaling pathway of this cytokine were also related to severe COVID-19.

Other Studies about Immunology:

Influence du sexe sur les anticorps neutralisants contre le SARS-CoV-2

Cette étude vise à déterminer les différences dans l’évolution de la réponse immunitaire dans les mois qui suivent l’infection par le SARS-CoV-2 chez les hommes et les femmes.

Prognostic Implications Of Neutrophil-Lymphocyte Ratio In COVID-19

This study aims to determine whether the neutrophil-to-lymphocyte ratio (NLR) can be useful in the diagnosis and treatment of COVID-19.

Risk Score For Predicting In-hospital Mortality In COVID-19

The RIM score, a simple and widely available tool that can help identify patients at risk of fatal COVID-19 outcomes.

CoViproteHCt

Identifying true markers of protective immunity will allow for the identification of individuals, in particular healthcare personnel working with COVID-19 patients and in other critical areas protected from re-infection.

Convalescent plasma therapy and COVID-19

Convalescent plasma with anti-SARS-CoV-2 antibodies appears to be a very promising approach in the context of protracted COVID-19 symptoms in patients unable to mount a specific humoral response to SARS-CoV-2.

COV-Immunity

Are you immunosuppressed? Engage this study and help underestand the kinetics of adaptive immunization against COVID-19.

Developing Therapies Based On The SARS-CoV-2 Cellular Response

This study aims to better understand the functioning of the immune response to SARS CoV-2 in order to propose new treatments based on the body’s cellular response to COVID-19.

Autoimmune and immune-mediated diseases and symptomatic COVID-19

This study analyses if patients with autoimmune diseases and coronavirus infection have a lower risk of developing severe COVID.