Progesterone for the Treatment of COVID-19

Can sex hormones help men survive COVID-19? This study assesses the safety and efficacy of progesterone for the treatment of COVID-19 in hospitalized men


What do you know about progesterone?

Progesterone is a steroid hormone that occurs naturally in the body, but it can also be made in a laboratory. It has a variety of important functions in the body and is involved in the menstrual cycle, pregnancy, and embryogenesis.

In addition to its role as a natural hormone, progesterone is also used as a medication in combination with estrogens, mainly in hormone therapy for menopausal symptoms, low sex hormone levels in women, or to treat gynecological disorders and to support pregnancy and fertility.

Description of the Study:

  • Title: A Single Center, Randomized, Controlled Trial of the Safety and Efficacy of Progesterone for the Treatment of COVID-19 in Hospitalized Men.
  • Principal Investigator: Sara Ghandehari.
  • Center of Implementation: Cedars Sinai Medical Center.
  • Study Population: 400 hospitalized adult men with COVID-19 that:
    – Have respiratory symptoms or abnormal lung exam or abnormal chest imaging and oxygen saturation ≤94% on room air, or requiring supplemental oxygen less than 50% high flow.
    – Have NOT ALT or AST >5 times the upper limit of normal, history of blood clots and breast cancer, allergy to progesterone or betacyclodextrin and do not require higher than 50% supplemental oxygen or mechanical ventilation.
  • Study Type: Randomized Interventional Clinical Trial.
  • Design: Progesterone 100 mg will be administered subcutaneously twice daily for 5 days in addition to institutional standard of care.

Objectives of the Study:

Principal Objective: The primary objective is to assess and study safety and efficacy of progesterone for treatment of COVID-19 in hospitalized men.

More about this Study:

Cedars-Sinai Medical Center: Cedars-Sinai is a non-profit academic health organization serving the diverse community of Los Angeles and beyond. They have pioneered medical research achievements, education programs that define the future of health care, and a wide range of community benefit activities, and are now setting new standards for quality and innovation in patient care.

Cedars Sinai supports this study about progesterone for treatment of COVID-19 in hospitalized men
Ibsa Pharma Logo

Other Clinical Trials:

CombivacS

Clinical trial designed to evaluate the safety and immunogenicity of a dose of Comirnaty vaccine (Pfizer) in people who have previously received a dose of…

E-speranza-COVID19 Project

This study aims to demonstrate efficacy of Montelukast for patients with persistent COVID-19 to help them improve their quality of life.

ANTICOV Study: COVID-19 in Africa

Collaborate with ANTICOV study to treat COVID-19 in Africa.

COnV-ert study, convalescent plasma to stop COVID-19

Early administration of convalescent plasma in people over 50 years of age with mild to moderate COVID-19 disease may slow disease progression and decrease the…

An antiviral mouthwash and COVID-19

Using a mouthwash containing β-cyclodextrin and citrox (bioflavonoids) (CDCM), available in pharmacies, helps reduce the SARS-CoV-2 viral load in saliva.

Pediatric COVID vaccination clinical trial

This pediatric clinical trial aims to test the safety, tolerability and immunogenicity of Pfizer's COVID vaccine in children under 12 years of age.

LacCOVID Study

The LacCOVID study has shown that milk from lactating women who have been vaccinated with Pfizer-BioNTech contains specific antibodies against the SARS-CoV-2 coronavirus.

Immunomodulatory Treatment In Patients With Severe Pneumonia COVID-19

Clinical trial to perform immunomodulatory treatment in adult patients with severe COVID-19 pneumonia with the aim of helping to define the standard treatment for this…

Prevention With Calcifediol Of Respiratory Problems Caused By COVID-19

This multicentre clinical trial aims to demonstrate that treatment with Calcifediol reduces the need for invasive ventilation and Intensive Care Unit admissions and deaths.

Maraviroc in patients hospitalized for COVID-19

Phase II clinical trial evaluating the safety and efficacy of the drug Maraviroc combined with standard therapy versus standard therapy in patients infected with SARS-CoV-2…