This study aims to determine the incidence of cardiovascular events associated with COVID-19 positive and negative patients in Catalonia
Description of the Study:
- Title: Incidència d’esdeveniments cardiovasculars en pacients COVID-19 a Catalunya.
- Principal Investigator: Mª Teresa Alzamora Sas.
- Center of Implementation: The study data come from the SIDIAP (Sistema d’Informació per al Desenvolupament de la Investigació en Atenció Primaria) database, which has 5.8 million citizens and 279 Primary Care Teams.
- Study Population: General Mediterranean population > 15 years old.
- Study Type: Observational study.
Objectives of the Study:
(1) To determine the incidence of vascular events: myocardial infarction, stroke, pulmonary thromboembolism, deep vein thrombosis and associated vascular and overall mortality in COVID-19 and non-COVID-19 patients during the first half of 2020.
(2) To compare the incidence of the aforementioned vascular events between the first half of 2019 and the first half of 2020.
(3) To analyse the associated risk factors.
More about this Study:
Scientific context: Despite numerous publications, the evidence on COVID-19 and cardiovascular events is currently rather inconsistent, due to the fact that it is an emerging disease. Among other things, there is a systemic inflammatory response (endothelial dysfunction and microthrombosi) and hypercoagulability (elevated D-dimer and fibrinogen). This inflammation increases the risk of atherosclerotic plaque rupture and thus vascular events. It is important to assess the cardiovascular complications that may contribute to the mortality associated with this pandemic.
Added value: This study is based on the hypothesis that COVID-19 patients have a higher incidence of cardiovascular events than non-COVID-19 patients. Therefore, the expected results are an increase in vascular events in COVID-19 patients compared to non-COVID-19 patients.
On the other hand, the results of this study can be applied to identify risk factors associated with the occurrence of a cardiovascular evenst in people with COVID-19 in order to be able to better prevent new outbreaks of this disease. In addition, it will identify the most susceptible individuals so that they can benefit from preventive measures or early diagnosis in an effective and efficient manner.
Finally, it will be of great relevance since knowing the real incidence of vascular events and the factors associated with their appearance will help to implement strategies for the prevention and management of this disease before vascular events occur.
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CIBERES UCI COVID is a fundamental study that will improve care of critical patients infected by COVID-19.