Sex Differences In The Evolution Of Neutralizing Antibodies To SARS-CoV-2

This study aims to determine the differences in the evolution of the immune response in the months following SARS-CoV-2 infection in men and women


Keywords: SARS-CoV-2; antibodies; sex-related differences; COVID-19.

Description of the Study:

  • Title: Sex differences in the evolution of neutralizing antibodies to SARS-CoV-2.
  • Principal Investigators: Ludivine Grzelak, Aurélie Velay, Yoann Madec, Floriane Gallais, Isabelle Staropoli, Catherine Schmidt-Mutter, Marie-Josée Wendling, Nicolas Meyer, Cyril Planchais, David Rey, Hugo Mouquet, Nathalie Reix, Ludovic Glady, Yves Hansmann, Timothée Bruel, Jérome De Sèze, Arnaud Fontanet, Maria Gonzalez, Olivier Schwartz and Samira Fafi-Kremer.
  • Centres of Implementation: Strasbourg University Hospital, France.
  • Study Population: 308 RT-qPCR+ healthcare workers with mild disease.
  • Study Type: Prospective, interventional, single-centre, longitudinal cohort study.
  • Design: Antibodies against SARS (S), nucleoprotein (N) and neutralising antibodies (NAbs) were measured in participants’ sera, collected at two time points up to 6 months after symptom onset.
  • Methods:
    – Statistical analysis
    – Serological assays

Objectives of the Study:

Principal Objective: To study the evolution of the immune response in the months following SARS-CoV-2 infection in men and women.

More about this Study:

Scientific Context: The duration of humoral immune responses to SARS-CoV-2 is a matter of debate. Patients with severe COVID-19 produce more antibodies than asymptomatic or mildly symptomatic individuals. Some studies showed a rapid decline in convalescents, regardless of disease severity, while others reported stable antibody titres in the first three months.

Anti-Spike (S) antibody amounts correlate with neutralising capacity, as S is the main, if not the only, target of neutralising antibodies. Neutralising antibody levels also vary according to the time since symptom onset (POS) and the severity of the disease. Little is known about the influence of sex, age and body mass index (BMI) on the longevity of anti-SARS-CoV-2 antibodies, especially in mildly symptomatic individuals, who represent the majority of COVID-19 cases.


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