SARS-CoV-2 in Partially Vaccinated Populations

This study aims to study how partial vaccination of the French population should change the epidemiology of SARS-CoV-2 and to determine the implications for epidemic control


Results:

– In the scenario characterised by 30%-70%-90% vaccination coverage among 12-17, 18-59 and ≥60 years old, a significant strain on health care is expected in the absence of measures.
– Unvaccinated individuals contribute 12 times more to transmission than vaccinated individuals.
– Unvaccinated adults ≥60 years account for 3% of the population, but 36% of hospitalisations.
– Given limited coverage, children aged 0-17 years account for about half of infections and disease transmitters.
– Non-pharmaceutical measures have a similar impact whether applied to all individuals or only to the unvaccinated.
– Of all the interventions considered, including repeated testing and non-pharmaceutical measures, vaccination of the unvaccinated is the most effective. Vaccination of children is important to protect them from the harmful effects of non-pharmaceutical measures.

Description of the Study:

  • Title: Epidemiology and control of SARS-CoV-2 epidemics in partially vaccinated populations: a modeling study applied to France.
  • Principal Investigators: Paolo Bosetti, Cécile Tran Kiem, Alessio Andronico, Vittoria Colizza, Yazdan Yazdanpanah, Arnaud Fontanet, Daniel Benamouzig and Simon Cauchemez.
  • Study Population: Individuals in metropolitan France.
  • Methods: An age-stratified deterministic compartmental model describing the spread of SARS-CoV-2 in metropolitan France was developed.

Objectives of the Study:

Principal Objective: To study and anticipate how partial vaccination of the French population should change the epidemiology of SARS-CoV-2 and to determine the implications for epidemic control.

More about this Study:

Scientific Context: The SARS-CoV-2 pandemic that began in December 2019 has caused more than 3.8 million deaths worldwide and brought health systems to the brink of collapse in many countries. Moreover, the drastic control measures that were implemented to limit its impact have had dramatic socio-economic consequences.

Vaccines have proven effective in reducing the severity of SARS-CoV-2 infection, the risk of infection and transmission. Their introduction offers a way out of this difficult period. However, given the high transmissibility and severity of SARS-CoV-2, very high vaccine coverage may be necessary to completely relax control measures. This goal may be difficult to achieve in countries, such as France, that are affected by vaccine hesitancy. In these places, SARS-CoV-2 may still be circulating in autumn 2021 and affect health systems. In this new era in which a substantial part of the population will be vaccinated, the epidemiology of SARS-CoV-2 should be different from before the distribution of the vaccines.
It is important to anticipate these changes to determine how control measures might evolve to ensure that they keep the epidemic under control while minimising costs to society.

Impression
Cso
Hopital Bichat A10db683043f49e992c0f362750e2413
Insermlogocomuesorbonneparisciteiau
Iplesp
640px Logosorbonneuniversite


Other Epidemiological Studies:

Effectiveness of vaccine combination

Científicos franceses demuestran que la vacunación primaria con dos vacunas diferentes sería más eficaz que la vacunación con dos vacunas idénticas.

The Social Perception Of COVID-19 Vaccines

This study conducted by the UOC aims to find out the opinion of the Spanish population and professional healthcare personnel on the COVID-19 vaccines.

CombivacS

Clinical trial designed to evaluate the safety and immunogenicity of a dose of Comirnaty vaccine (Pfizer) in people who have previously received a dose of Vaxcevria vaccine (AstraZeneca).

MOOD-COVID

MOOD-COVID aims to study the impact of the pandemic on the mental health of pregnant women, young mothers and their children.

Emotional State Of Adults In The Process Of Bereavement By COVID-19

This study aims to analyse the emotional and spiritual state of adults who have lost a loved one due to COVID-19.

E-speranza-COVID19 Project

This study aims to demonstrate efficacy of Montelukast for patients with persistent COVID-19 to help them improve their quality of life.

Early Corticosteroid Treatment for COVID-19

This study proposal aims to determine whether early corticosteroid treatment can reduce the need for oxygen therapy and post-COVID sequelae.

MINDCOVID: Mental Health in a Pandemic

This study aims to assess the mental health impact and needs associated with COVID-19 in Spain.

CIBERESUCI COVID

CIBERES UCI COVID is a fundamental study that will improve care of critical patients infected by COVID-19.

NAUTILUS Project

The NAUTILUS project aims to develop an artificial intelligence platform to identify, predict and intervene on persistent symptoms in people who have suffered from COVID-19.