SAPRIS-SERO is a study to estimate the seroprevalence of SARS-CoV-2 infection in the epidemiological cohorts Constances, E3-E4N, NutriNet-Santé and Elfe-Epipage2 in France
Description of the Study:
- Title: Seroprevalence of SARS-CoV-2 among adults in three regions of France following the lockdown and associated risk factors: a multicohort study.
- Principal Investigator: Fabrice Carrat.
- Co-Investigators: Marie Zins, Gianluca Severi, Mathilde Touvier, Marie-Aline Charles and Pierre-Yves Ancel.
- Study Population: 14,600 participants interviewed during the first confinement of the Constances, E3N-E4N, Elfe, Epipage and NutriNet-Santé cohorts.
- Study Type: Prospective observational study.
- Design: Firstly, participants were questioned on several occasions about their conditions of confinement, their possible symptoms and medical follow-up. Secondly, participants in a COVID-19 survey of an existing consortium of three general adult population cohorts living in Ile-de-France (IDF) or Grand Est (GE) – two regions with a high rate of COVID-19 – or in Nouvelle-Aquitaine (NA) – with a low rate – were asked to have a dried-blood spot (DBS) to assess anti-SARS-CoV-2 antibodies.
– The primary outcome was a positive anti-SARS-CoV-2 IgG ELISA result against the virus spike protein (S-ELISA).
– Secondary outcomes were a positive IgG ELISA result against nucleocapsid protein (ELISA-NP), anti-SARS-CoV-2 neutralising antibody values ≥40 (SN), and predicted positivity obtained from a multiple imputation (MI) model.
– Prevalence estimates were adjusted using sampling weights and post-stratification methods.
Objectives of the Study:
Principal Objective: To estimate the seroprevalence of SARS-CoV-2 infection, between May and June 2020 after confinement, in adults living in three regions of France and to identify associated risk factors.
More about this Study:
Scientific Context: At the end of February 2020, the idea arose to ask participants of the E3N-E4N epidemiological study to advance research on the new coronavirus (SARS-CoV-2). These volunteers have been helping health research for the past 30 years to a large extent by regularly answering questionnaires about their health and lifestyle and by giving biological samples (blood, saliva). Used to contributing to research on cancer and major chronic diseases, now it is time to help understand a new infectious disease to which they are called.
Other Studies about Serology:
Científicos franceses demuestran que la vacunación primaria con dos vacunas diferentes sería más eficaz que la vacunación con dos vacunas idénticas.
Determining whether there is protection against reinfection is important for controlling healthcare workers implications during the pandemic due to their continous professional contact with COVID-19 patients
Early administration of convalescent plasma in people over 50 years of age with mild to moderate COVID-19 disease may slow disease progression and decrease the severity of symptoms.
This study aims to estimate the prevalence of antibodies against SARS-CoV-2 and help improve the prediction of infectious diseases and increase biosecurity in the Principality of Andorra.
Identifying true markers of protective immunity will allow for the identification of individuals, in particular healthcare personnel working with COVID-19 patients and in other critical areas protected from re-infection.
The COVICAT study aims to evaluate the evolution of the incidence of SARS-CoV-2 coronavirus infection in the Catalan population over a 12-month period.
Convalescent plasma with anti-SARS-CoV-2 antibodies appears to be a very promising approach in the context of protracted COVID-19 symptoms in patients unable to mount a specific humoral response to SARS-CoV-2.
The EpiCOV project aims to provide a global and scientifically reliable mapping of the immune status of the population in France through serological tests and questionnaires.