NAUTILUS Project

The NAUTILUS project aims to develop an artificial intelligence platform to identify, predict and intervene on persistent symptoms in people who have suffered from COVID-19


There are many questions that we cannot answer, but we know that there are different mechanisms and causes that can affect the brain. We do not know what these mechanisms are and in whom it can appear, nor do we know what the entry point of the virus into our brain is.

DR Maite Garolera Freixa

Description of the Study:

  • Title: Cognition, emotion/behaviour, functionality and brain connectivity in patients recovered from Covid-19 (NAUTILUS).
  • Principal Investigators: Maite Garolera Freixa, Bàrbara Segura Fàbregas y Claudio Ulises Cortés Garcia.
  • Coordinating Centres: Led by the Consorci Sanitari de Terrassa, the UB, the UPC and the neuropsychology teams of 22 public hospitals and promoted by Fundació La Marató de TV3 2020.
  • Methods: Based on a study to detect the discriminatory potential of multimodal biomarkers in adverse outcomes of COVID-19, the aim is to develop an artificial intelligence platform to identify, predict and intervene on persistent symptoms in people who have suffered COVID-19.

Objectives of the Study:

Principal Objectives:
(1) To develop an artificial intelligence platform to identify, predict and intervene on persistent symptoms in people who have suffered from COVID-19.
(2) To identify the determinants (premorbid, behavioural, biological and brain imaging) that cause some COVID-19 sufferers to suffer persistent symptoms using predictive models based on machine learning.
(3) Create a digital platform, incorporating different companies that can provide a solution to the need to treat the symptoms of people with persistent COVID-19.

More about this Study:

Scientific Context: Between 40 and 60% of people admitted to the ICU for COVID-19 present neurological problems: headache, dizziness, loss of smell, epileptic seizures… and this is what led us to think that the virus can attack the brain.

It is known that people who have had the most severe disease have more cognitive difficulties or alterations. Some of the alterations are: lack of attention, difficulties in organising themselves, not being able to find words well or feeling that their thinking is slow. Another fact is that some people who have had mild COVID-19 also have cognitive impairment.

These alterations appear with the disease and when it ends, they leave after-effects, which is called persistent Covid and represents 10% of the people who have suffered from the virus.

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