Identifying true markers of protective immunity will allow for the identification of individuals, in particular healthcare personnel working with COVID-19 patients and in other critical areas protected from re-infection

We are not yet sure how to define the protective immune response, which is necessary for vaccine development and to safely get people back to work.”

PROF Dr. Markus

Description of the Study:

  • Title: CoViproteHCt.
  • Principal investigator: Markus Gerhard.
  • Centers of Implementation: Technische Universität München (TUM), Fundacion Privada Instituto de Salud Global Barcelona (ISGLOBAL), the University of Barcelona and Mikrogen GmbH.
  • Study Population: Healthcare personnel who have tested positive for SARS CoV-2.
  • Methods: The project team will collect blood samples from healthcare personnel who have tested positive for SARS CoV-2 and follow their health status for 6 months. Their blood will be tested for various antibody markers that are currently being used by different research teams to develop assays for COVID-19 immunity. By comparing blood content with the actual health of the individuals involved, it will be possible to determine which types of assays measure truly protective immunity.

Objectives of the Study:

Principal Objective: To develop and validate assays to characterise protective immune responses that can be used to identify individuals with COVID-19 immunity.

More about this Study:

Identifying true markers of protective immunity will allow for the identification of individuals protected from re-infection. The primary beneficiaries would be healthcare personnel, who would know whether they are safe in environments with a high risk of exposure, and society will benefit from maintenance of a functioning healthcare workforce. Identifying the assays that truly determine immunity will also make it possible to allow large portions of the population to return to economic activity. In addition, the validated assays can be used in future vaccine trials, to determine the effectiveness of experimental vaccines.


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CIBERES UCI COVID is a fundamental study that will improve care of critical patients infected by COVID-19.


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