Prognostic factors in COVID-19 patients

Determining the clinical, biological and radiological characteristics of patients with suspected COVID-19 infection is the key to treatment and isolation of contacts between individuals.

Keywords: COVID-19; SARS-Cov-2; Primary healthcare


Images of some of the results obtained

Prognostic factors for death and ICU admission
Prognostic factors for hospitalization

Description of the Study:

  • Title: Prognostic factors in spanish COVID-19 patients: A case series from barcelona.
  • Principal investigator: Antoni Sisó-Almirall.
  • Co-investigators: Belchin Kostov, Minerva Mas-Heredia, Sergi Vilanova-Rotllan, Ethel Sequeira-Aymar, Mireia Sans-Corrales, Elisenda Sant-Arderiu, Laia Cayuelas-Redondo, Angela Martínez-Pérez, Noemí García Plana, August Anguita-Guimet and Jaume Benavent-Àreu.
  • Centers of Implementation: Consorci d’Atenció Primària de Salut Barcelona Esquerre (CAPSBE) and Grup Tranversal de Recerca en Atenció Primària en el Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) de Barcelona. The three primary healthcare centers of Barcelona Esquerre: Centre d’Atenció Primària Les Corts, Centre d’Atenció Primària Casanova and Centre d’Atenció Primària Comte Borrell.
  • Study Population: 322 patients included (mean age 56.7 years, 50% female, 115 (35.7%) aged ≥ 65 years).
  • Study Type: Multicentric, descriptive, observational study.
  • Design: Descriptive, observational and retrospective study in three primary healthcare centres with an assigned population of 100,000.
  • Methods: Examination of the medical records of patients with COVID-19 infections confirmed by polymerase chain reaction. Logistic multivariate regression models adjusted for age and sex were constructed to analyse independent predictive factors associated with death, ICU admission and hospitalization.

Objectives of the Study:

Principal Objective: To determine clinical factors of a poor prognosis in patients with COVID-19 infection.

More about this Study:

Scientific context: In addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community.

The most common signs of infection are respiratory symptoms: fever, cough and shortness of breath. In more severe cases, the infection may cause pneumonia, severe acute respiratory syndrome, renal failure and death. Transmission appears to be mainly person-to-person via the airway through respiratory droplets measuring > 5 microns when the patient has respiratory symptoms (cough and sneezing) and contact with fomites. Most estimates of the incubation period of COVID-19 range from 1 to 14 days, with most around five days. Evidence on the transmission of the virus before symptom onset is unclear.

This study aimed to describe the clinical, biological and radiological manifestations, the evolution, treatments and mortality rate of patients with COVID-19 infection in the population of Barcelona city and determine the most important predictors of a poor prognosis.

Idibaps 1

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