EPICO Study

A national register to study how COVID-19 behaves in the pediatric population, its impact on the global epidemic, and its consequences on the child and youth population


Do you want to get answers to the unknown questions regarding the behavior of this virus in the pediatric patients?

Description of the Study:

  • Title: Estudio epidemiológico de las infecciones respiratorias por el nuevo Coronavirus (SARS-CoV-2) en población pediátrica.
  • Principal Investigators: Dr. Alfredo Tagarro and Dra. Cinta Moraleda.
  • Centers of Implementation: Hospital Universitario 12 de Octubre, Hospital Universitario Clínico San Carlos, Hospital Universitario Fundación Jiménez Díaz, Hospital Universitario Infanta Sofía, Hospital Universitario La Paz et al.
  • Study Population: All patients under 17 years of age, with SARS-CoV-2 confirmed infection by PCR.
  • Study Type: Epidemiological study.

Objectives of the Study:

Principal Objectives:
(1) Over the next 2 seasons, determine the incidence of SARSCoV-2 infection in children treated for respiratory infections, assessing whether it can generate epidemic peaks similar to respiratory syncytial virus (RSV) and flu virus.
(2) Describe the spectrum of disease, including time of transmission, associated with SARS-CoV-2 infection in different pediatric age groups.
(3) Describe the mortality and complication rate in pediatric patients with SARS-CoV-2 respiratory infection.
(4) To predict the risk of mortality and complications depending on the clinical, epidemiological and analytical characteristics and the treatment received.
(5) To analyze the implications of co-infections in the evolution of cases of SARS-CoV-2 infection.
(6)To analyze the effect of available antivirals on morbi-mortality in cases of viral co-infections.
(7) Prepare a rapid response network to other potential epidemics of respiratory pathogens, coordinated with international networks such as the European network PREPARE.
(8) Assess the medium-term sequelae of SARS-CoV-2 infection.

More about this Study:

EPICO project: Initiated in January 2020, aims to study mainly the natural history and risk factors for poor evolution in pediatric patients infected by SARS-CoV-2 in the next 2 years in Spain. In addition, genetic and immunological markers of the host will be identified to predict the susceptibility to complications associated with the infection by COVID-19 that will allow to evaluate the risks and eventually lead to the development of new therapeutic solutions. This project will also result in a register to study how COVID-19 behaves in the pediatric population.

Added value: The EPICO project, which involves several pediatric teams in Madrid, coordinated through the Institute of Investigation of the University Hospital 12 de Octubre, has been supported and financed by Asociación Española de Pediatría (AEP).


Hospital 12 Octubre has collaborated with the EPICO project to create a register to study how COVID-19 behaves in the pediatric population.
Hospital Clinico San Carlos has collaborated with the EPICO project to create a register to study how COVID-19 behaves in the pediatric population.
Fundación Jiménez Díaz has collaborated with the EPICO project to create a register to study how COVID-19 behaves in the pediatric population.
Hospital Universitario Infanta Sofía has collaborated with the EPICO project to create a register to study how COVID-19 behaves in the pediatric population.
Hospital Universitario La Paz has collaborated with the EPICO project to create a register to study how COVID-19 behaves in the pediatric population.

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